Inhomogeneity of Hemoglobin. VI. The Minor Hemoglobin Components of Cord Blood-Reference-Cited by-同舟云学术

Inhomogeneity of Hemoglobin. VI. The Minor Hemoglobin Components of Cord Blood

Published:1962-09-01 Issue:3 Volume:20 Page:302-314
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

HORTON BENNETT F.¹²,THOMPSON ROBERT B.¹³,DOZY ANDREE M.¹⁴,NECHTMAN CARL M.¹⁵,NICHOLS EVAN¹⁶,HUISMAN TITUS H. J.¹⁷

Affiliation:

1. Departments of Biochemistry, Pathology, and Obstetrics and Gynecology, Medical College of Georgia, Augusta, Ga.

2. Department of Biochemistry, Medical College of Georgia. At present, Research Fellow, Division of Hematology, Department of Medicine, Medical College of Georgia, Augusta, Ga.

3. Department of Pathology, Medical College of Georgia and Eugene Talmadge Memorial Hospital; Attending Consultant, V. A. Hospital, Augusta, Ga.

4. Hemoglobin Research Laboratory, Department of Biochemistry, Medical College of Georgia, Augusta, Ga.

5. Medical College of Georgia Graduate School, Department of Biochemistry, Medical College of Georgia, Augusta, Ga.

6. Medical College of Georgia and Eugene Talmadge Memorial Hospital, Augusta, Ga.

7. Medical College of Georgia and Eugene Talinadge Memorial Hospital, Augusta, Ga.

Abstract

Abstract In a survey of over 300 cord bloods of Negro babies, some 54 cases were selected at random to study the occurrence of the minor hemoglobin components Hb-Bart’s, Hb-H, and Hb-A2. The relationship of these components to Hb-F is discussed. Seven cases with moderate amounts of Hb-Bart’s and Hb-H were studied more intensively, along with the respective parents when possible. The findings suggest the absence of expression beyond infancy of any abnormality responsible for α chain-lacking hemoglobin types of cord blood. The physiology of Hb-Bart’s reveals its high oxygen affinity to be approximately 8-10 times that of Hb-A, its lack of a Bohr effect and an oxygen dissociation curve showing no heme-heme interaction. The discovery of a minute amount of a Hb-Gower II-like component in a cord blood sample of a prematurely born white baby of 7.5 months is also presented.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/20/3/302/570679/302.pdf

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