Studies on the Antimitotic Activity of Leurocristine (Vincristine)-Reference-Cited by-同舟云学术

Studies on the Antimitotic Activity of Leurocristine (Vincristine)

Published:1963-01-01 Issue:1 Volume:21 Page:102-110
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

CARDINALI GIUSEPPE¹²,CARDINALI GIULIANA¹³,ENEIN MOSTAFA ABOUL¹⁴

Affiliation:

1. Laboratories of Experimental Hematology, The Children’s Cancer Research Foundation, and the Department of Pathology, Harvard Medical School at The Children’s Hospital, Boston, Mass.

2. The Children's Cancer Research Foundation and the Departments of Pathology, The Children's Ho,spital Medical Center and Harvard Medical School, Boston, Mass.

3. The Children's Cancer Research Foundation and the Department of Pathology, The Children's Hospital Medical Center, Boston, Mass.

4. The Children's Cancer Research Foundation and the Department of Pathology, The Children's Hospital Methcal Center, Boston, Mass.

Abstract

Abstract The effect of leurocristine (vincristine) on cell division was studied in normal bone marrow and leukemic cells (L1210 leukemia) of DBA/2 mice. It was found that vincristine possesses the ability to arrest mitosis at the metaphase stage. The accumulation of arrested metaphases in the normal bone marrow and in leukemic cells of the animals treated with vincristine followed a pattern similar to the one observed after treatment with colchicine or vincaleukoblastine (vinblastine).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/21/1/102/571120/102.pdf

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