Evidence-based management of pregnant women with sickle cell disease in high-income countries

Author:

Oteng-Ntim Eugene12,Shangaris Panicos123

Affiliation:

1. 1 School of Life Course and Population Sciences, King's College London, St Thomas' Hospital, London, UK

2. 2 Department of Women and Children, Guy's and St Thomas' NHS Foundation Trust, London, UK

3. 3 Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK

Abstract

Abstract Globally, patients living with sickle cell disease are now surviving to reproductive age, with life expectancy approaching 50 years in most countries. Thus, reproductive options are now essential for patients living with the condition. However, it can be associated with maternal, delivery, and fetal complications. Outcomes may vary depending on the level of expertise and resources. In this piece we provide an optional guideline for managing sickle cell disease in pregnancy. The therapeutic option of serial exchange prophylactic transfusion has been offered in the context of a clinical trial (TAPS2).

Publisher

American Society of Hematology

Subject

Hematology

Reference30 articles.

1. Management of sickle cell disease in pregnancy. A British Society for Haematology Guideline;Oteng-Ntim;Br J Haematol,2021

2. Royal College of Obstetricians and Gynaecologists. Management of sickle cell disease in pregnancy. Accessed 8September2022. https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/sickle-cell-disease-in-pregnancy-management-of-green-top-guideline-no-61/.

3. Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates;Piel;Lancet,2013

4. Pregnancy outcome in patients with sickle cell disease in the UK—a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease;Oteng-Ntim;Br J Haematol,2015

5. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis;Oteng-Ntim;Blood,2015

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