Human erythroid porphobilinogen deaminase exists in 2 splice variants-Reference-Cited by-同舟云学术

Human erythroid porphobilinogen deaminase exists in 2 splice variants

Published:2001-02-01 Issue:3 Volume:97 Page:815-817
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Gubin Alexander N.¹,Miller Jeffery L.¹

Affiliation:

1. From the Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Abstract

AbstractHuman porphobilinogen deaminase (PBGD) is, reportedly, encoded by 2 distinct messenger RNAs (mRNAs) transcribing from a single gene. The ubiquitous form of the PBGD gene product is often used as an endogenous reference in gene expression studies because it is pseudogene free and has minimal transcriptional variability among tissues. A distinct erythroid-specific gene product has also been described because of the alternate splicing of the gene. Here is reported the existence of an additional erythroid-specific isoform of PBGD mRNA in primary cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/97/3/815/1671265/815.pdf

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