Admixture facilitates genetic adaptations to high altitude in Tibet-Reference-Cited by-同舟云学术

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Admixture facilitates genetic adaptations to high altitude in Tibet

Published:2014-02-10 Issue:1 Volume:5 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Jeong Choongwon,Alkorta-Aranburu Gorka,Basnyat Buddha,Neupane Maniraj,Witonsky David B.,Pritchard Jonathan K.,Beall Cynthia M.,Di Rienzo Anna

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms4281.pdf

Reference56 articles.

1. Storz, J. F., Scott, G. R. & Cheviron, Z. A. Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. J. Exp. Biol. 213, 4125–4136 (2010).

2. Beall, C. M., Song, K., Elston, R. C. & Goldstein, M. C. Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4000, m. Proc. Natl Acad. Sci. USA 101, 14300–14304 (2004).

3. Beall, C. M. et al. Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. Proc. Natl Acad. Sci. USA 107, 11459–11464 (2010).

4. Simonson, T. S. et al. Genetic evidence for high-altitude adaptation in Tibet. Science 329, 72–75 (2010).

5. Yi, X. et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329, 75–78 (2010).

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