Radioisotopic Assay for Measurement of Serum Folate Levels

Author:

WAXMAN SAMUEL12,SCHREIBER CAROL12,HERBERT VICTOR13

Affiliation:

1. Department of Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y.; Department of Medicine, VA Hospital, Bronx, N.Y.; and Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, N.Y.

2. Mount Sinai School of Medicine of the City University of New York, New York, N. Y.

3. Veterans Administration; Clinical Professor of Pathology, College of Physicians & Surgeons, Columbia University, New York, N.).; recipient of Health Research Council of the City of New York Career Scientist Award 1-683.

Abstract

Abstract A radioisotopic assay is reported that accurately measures an almost identical serum folate to that measured by Lactobacillus casei and can separate low, borderline, and normal folate levels. This assay utilizes a powdered milk available in any grocery. The assay takes less than 4 hr and can be run in unlimited quantity. This radioassay should simplify diagnosis of folate deficiency and be particularly useful in patients receiving antibiotics and folate antagonists, where the microbiological assay gives false low results.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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