Transmission of Toxoplasmosis by Leukocyte Transfusion

Author:

SIEGEL STUART E.12,LUNDE MILFORD N.13,GELDERMAN ALBERT H.13,HALTERMAN ROGER H.12,BROWN JAMES A.12,LEVINE ARTHUR S.12,GRAW ROBERT G.14

Affiliation:

1. Leukemia Service, Medicine Branch, and Human Tumor Cell Biology Branch, National Cancer Institute, Bethesda, Md., and the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, Bethesda, Md.

2. Leukemia Service, Medicine Branch, National Cancer Institute, Bethesda, Md.

3. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, Bethesda, Md.

4. Human Tumor Cell Biology Branch, National Cancer Institute, Bethesda, Md.

Abstract

Abstract Four patients with acute leukemia developed toxoplasmosis following leukocyte transfusions from donors with chronic myelogenous leukemia. Serologic data, obtained from the donors retrospectively, revealed elevated antitoxoplasma antibody titers, suggesting that the transfused leukocytes were the source of the organism in the recipients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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