Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity
Author:
Affiliation:
1. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom;
2. The Institute of Cancer Research, London, United Kingdom; and
3. School of Biosciences and Phenome Centre Birmingham and
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/136/10/1155/1756922/bloodbld2019004500.pdf
Reference25 articles.
1. Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia;Park;N Engl J Med,2018
2. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma;Louis;Blood,2011
3. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies;Beatty;Cancer Immunol Res,2014
4. MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers;Fultang;EBioMedicine,2019
5. Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment;Mussai;Blood,2013
Cited by 101 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Advanced Strategies of CAR-T Cell Therapy in Solid Tumors and Hematological Malignancies;Recent Patents on Anti-Cancer Drug Discovery;2024-12
2. T cell exhaustion in human cancers;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2024-09
3. Metabolic profiling using benchtop NMR identifies the metabolomic signature of persistent CAR-T cells;2024-07-23
4. Fueling CARs: metabolic strategies to enhance CAR T-cell therapy;Experimental Hematology & Oncology;2024-07-10
5. Genetically engineering glycolysis in T cells increases their antitumor function;Journal for ImmunoTherapy of Cancer;2024-07
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3