Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Author:

Mussai Francis1,De Santo Carmela1,Abu-Dayyeh Issa1,Booth Sarah1,Quek Lynn2,McEwen-Smith Rosanna M.1,Qureshi Amrana3,Dazzi Francesco4,Vyas Paresh2,Cerundolo Vincenzo1

Affiliation:

1. Medical Research Council Human Immunology Unit and

2. Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;

3. Department of Paediatric Oncology, Children’s Hospital, John Radcliffe Hospital, Oxford, United Kingdom; and

4. Department of Haematology, Hammersmith Hospital, London, United Kingdom

Abstract

Key Points AML blasts have an arginase-dependent ability to inhibit T-cell proliferation and hematopoietic stem cells. AML blasts have an arginase-dependent ability to modulate the polarization of monocytes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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