Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis-Reference-Cited by-同舟云学术

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Published:2019-10-02 Issue:21 Volume:134 Page:1847-1858
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Geue Sascha¹,Aurbach Katja²³,Manke Mailin-Christin¹,Manukjan Georgi³,Münzer Patrick¹,Stegner David²³^ORCID,Brähler Caroline³,Walker-Allgaier Britta¹,Märklin Melanie⁴,Borst Carla E.⁵,Quintanilla-Fend Leticia⁶^ORCID,Rath Dominik¹,Geisler Tobias¹,Salih Helmut R.⁴,Seizer Peter¹,Lang Florian¹⁷^ORCID,Nieswandt Bernhard²³^ORCID,Gawaz Meinrad¹,Schulze Harald³^ORCID,Pleines Irina²³^ORCID,Borst Oliver¹

Affiliation:

1. Department of Cardiology, Angiology, and Cardiovascular Medicine, University of Tübingen, Tübingen, Germany;

2. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany;

3. Institute of Experimental Biomedicine, University Hospital of Würzburg, Würzburg, Germany;

4. Clinical Cooperation Unit Translational Immunology, German Cancer Consortium (DKTK), DKFZ Partner Site Tübingen, Tübingen, Germany; and

5. Department of Hematology and Oncology,

6. Department of Pathology, and

7. Department of Physiology, University of Tübingen, Tübingen, Germany

Abstract

The investigators explore the role of PDK1 (phosphoinositide-dependent protein kinase 1) in the cytoskeletal regulation of platelet production and furnish new insights into megakaryocyte maturation and proplatelet formation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/21/1847/1541418/bloodbld2019000185.pdf

Reference54 articles.

1. CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis;Münzer;Blood,2017

2. The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling;Borst;Circ Res,2012

3. The biogenesis of platelets from megakaryocyte proplatelets;Patel;J Clin Invest,2005

4. The incredible journey: from megakaryocyte development to platelet formation;Machlus;J Cell Biol,2013

5. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis;Schulze;Blood,2006

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