Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Author:

O’Byrne Sorcha1ORCID,Elliott Natalina1,Rice Siobhan2,Buck Gemma12,Fordham Nicholas2,Garnett Catherine2,Godfrey Laura2,Crump Nicholas T.2ORCID,Wright Gary3,Inglott Sarah3,Hua Peng24ORCID,Psaila Bethan2ORCID,Povinelli Benjamin2,Knapp David J. H. F.2ORCID,Agraz-Doblas Antonio56,Bueno Clara6,Varela Ignacio5,Bennett Phillip7,Koohy Hashem8,Watt Suzanne M.4,Karadimitris Anastasios9,Mead Adam J.210,Ancliff Phillip3,Vyas Paresh210ORCID,Menendez Pablo61112,Milne Thomas A.210ORCID,Roberts Irene1210,Roy Anindita1ORCID

Affiliation:

1. Department of Paediatrics and

2. Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom;

3. Department of Haematology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom;

4. Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom;

5. Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria–CSIC, Santander, Spain;

6. Josep Carreras Leukemia Research Institute–Campus Clinic, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain;

7. Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom;

8. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;

9. Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom;

10. Haematology Theme, Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, United Kingdom;

11. Institucio Catalana of Recerca i Estudis Avançats, Barcelona, Spain; and

12. Centro de Investigación Biomédica en Red en Cancer–ISCIII, Barcelona, Spain

Abstract

Abstract By comparing fetal and adult B-lymphopoiesis, the authors identify a prepro–B-cell subset in humans that marks the origin of B-cell lineage commitment in utero.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference48 articles.

1. Development of pre-B and B lymphocytes in the human fetus;Asma;Clin Exp Immunol,1984

2. Immunophenotypic analysis and quantification of B-1 and B-2 B cells during human fetal hematopoietic development;Bueno;Leukemia,2016

3. Immunobiologic differences between normal and leukemic human B-cell precursors;Uckun;Proc Natl Acad Sci U S A,1988

4. B cells are generated throughout life in humans;Nuñez;J Immunol,1996

5. Early ontogeny of the human marrow from long bones: an immunohistochemical study of hematopoiesis and its microenvironment;Charbord;Blood,1996

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