Impact of NFE2 mutations on AML transformation and overall survival in patients with myeloproliferative neoplasms

Author:

Marcault Clémence1ORCID,Zhao Lin-Pierre1,Maslah Nabih23ORCID,Verger Emmanuelle23ORCID,Daltro de Oliveira Rafael1ORCID,Soret-Dulphy Juliette1,Cazaux Marine1,Gauthier Nicolas1ORCID,Roux Blandine4,Clappier Emmanuelle45,Parquet Nathalie6,Dosquet Christine2,Réa Delphine6ORCID,Zini Jean-Marc6,Vainchenker William6ORCID,Raffoux Emmanuel6,Giraudier Stéphane23,Kiladjian Jean-Jacques13ORCID,Cassinat Bruno23ORCID,Benajiba Lina14ORCID

Affiliation:

1. Université de Paris, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Centre d’Investigations Cliniques, INSERM Centre d'Investigations Cliniques (CIC) 1427, Paris, France;

2. Université de Paris, AP-HP, Hôpital Saint-Louis, Laboratoire de Biologie Cellulaire, Paris, France;

3. INSERM Unité Mixte de Recherche (UMR) 1131, Institut de Recherche Saint-Louis, Paris, France;

4. INSERM UMR 944, Institut de Recherche Saint-Louis, Paris, France;

5. Université de Paris, AP-HP, Hôpital Saint-Louis, Laboratoire d’Hématologie Biologique, Paris, France; and

6. Université de Paris, AP-HP, Hôpital Saint-Louis, Département d’Hématologie Clinique, Paris, France

Abstract

Marcault et al report the impact of NFE2 mutations on the prognosis of patients with myeloproliferative neoplasms (MPNs) in a study of over 700 patients for whom sequential next-generation sequencing was available. NFE2 mutations were reported in 9.1% of patients and predicted for increased transformation and decreased survival. Since histone deacetylase (HDAC) inhibitors decrease NFE2 levels, patients with NFE2 mutations may benefit from HDAC inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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