Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms-Reference-Cited by-同舟云学术

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

Published:2018-05-03 Issue:18 Volume:131 Page:2065-2073
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Peeken Jan C.¹^ORCID,Jutzi Jonas S.¹²³^ORCID,Wehrle Julius¹⁴⁵⁶,Koellerer Christoph¹,Staehle Hans F.¹,Becker Heiko¹,Schoenwandt Elias¹,Seeger Thalia S.¹,Schanne Daniel H.¹,Gothwal Monika¹,Ott Christopher J.⁷⁸,Gründer Albert¹,Pahl Heike L.¹²^ORCID

Affiliation:

1. Division of Molecular Hematology,

2. Spemann Graduate School of Biology and Medicine (SGBM),

3. Faculty of Biology, and

4. Berta Ottenstein Program, Faculty of Medicine, University of Freiburg, Freiburg, Germany;

5. German Cancer Consortium (DKTK), Freiburg, Germany;

6. German Cancer Research Center (DKFZ), Heidelberg, Germany;

7. Center for Cancer Research, Massachusetts General Hospital, Boston, MA; and

8. Department of Medicine, Harvard Medical School, Charlestown, MA

Abstract

Key Points Overexpression of NFE2 in MPNs is associated with H3Y41 phosphorylation by JAK2V617F. JMJD1C is an NFE2 target gene and acts in a positive feedback loop contributing to NFE2 overexpression in MPNs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/18/2065/1406032/blood810622.pdf

Reference27 articles.

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4. A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2;Kaufmann;J Exp Med,2012

5. MPN patients harbor recurrent truncating mutations in transcription factor NF-E2;Jutzi;J Exp Med,2013

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