<i>BRAF</i> V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis-Reference-Cited by-同舟云学术

BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Published:2023-11-02 Issue:18 Volume:142 Page:1570-1575
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Acosta-Medina Aldo A.¹²^ORCID,Kemps Paul G.³^ORCID,Zondag Timo C. E.⁴^ORCID,Abeykoon Jithma P.²^ORCID,Forma-Borst Jelske⁵,Steenwijk Eline C.⁵,Feijen Elizabeth A. M.⁶^ORCID,Teepen Jop C.⁶^ORCID,Bennani N. Nora²^ORCID,Schram Susan M.²,Shah Mithun V.²^ORCID,Davidge-Pitts Caroline⁷^ORCID,Koster Matthew J.⁸^ORCID,Ryu Jay H.⁹^ORCID,Vassallo Robert⁹,Tobin W. Oliver¹⁰^ORCID,Young Jason R.¹¹^ORCID,Dasari Surendra¹²^ORCID,Rech Karen¹³^ORCID,Ravindran Aishwarya¹⁴^ORCID,Cleven Arjen H. G.³¹⁵^ORCID,Verdijk Robert M.³¹⁶^ORCID,van Noesel Carel J. M.¹⁷^ORCID,Balgobind Brian V.¹⁸^ORCID,Bouma Gerrit Joan¹⁹^ORCID,Saeed Peerooz²⁰^ORCID,Bramer Jos A. M.⁶²¹^ORCID,de Groen Ruben A. L.²²^ORCID,Vermaat Joost S. P.²²^ORCID,van de Sande Michiel A. J.⁶²³^ORCID,Smit Egbert F.²⁴^ORCID,Langerak Anton W.²⁵^ORCID,van Wezel Tom³^ORCID,Tonino Sanne H.²⁶^ORCID,van den Bos Cor⁶²⁷^ORCID,van Laar Jan A. M.⁴²⁸^ORCID,Go Ronald S.²^ORCID,Goyal Gaurav²²⁹^ORCID,van Halteren Astrid G. S.³⁴⁶^ORCID

Affiliation:

1. 1Department of Internal Medicine, Mayo Clinic, Rochester, MN

2. 2Division of Hematology, Mayo Clinic, Rochester, MN

3. 3Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

4. 4Section Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

5. 5Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

6. 6Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

7. 7Division of Endocrinology, Mayo Clinic, Rochester, MN

8. 8Division of Rheumatology, Mayo Clinic, Rochester, MN

9. 9Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN

10. 10Department of Neurology, Mayo Clinic, Rochester, MN

11. 11Department of Radiology, Mayo Clinic, Jacksonville, FL

12. 12Division of Biomedical Statistics and Informatics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN

13. 13Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

14. 14Department of Pathology, University of Alabama at Birmingham, Birmingham, AL

15. 15Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands

16. 16Department of Pathology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

17. 17Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands

18. 18Department of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands

19. 19Department of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands

20. 20Department of Ophthalmology, Orbital Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands

21. 21Department of Orthopedic Surgery and Sports Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands

22. 22Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

23. 23Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

24. 24Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands

25. 25Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

26. 26Department of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands

27. 27Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands

28. 28Section Clinical Immunology, Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

29. 29Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL

Abstract

Abstract In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/142/18/1570/2087301/blood_bld-2023-021212-main.pdf

Reference17 articles.

1. International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults;Goyal;Blood,2022

2. The coming of age of Langerhans cell histiocytosis;Allen;Nat Immunol,2020

3. BRAF mutation correlates with high-risk Langerhans cell histiocytosis and increased resistance to first-line therapy;Héritier;J Clin Oncol,2016

4. Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study;Kemps;Blood Adv,2023

5. Bone marrow–derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis;Xiao;Blood,2020

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