Langerhans cell histiocytosis of the suprasellar region: diagnosis based on thyroid cytology

Author:

Mavromati Maria12ORCID,Caironi Verdiana3,Saiji Essia42,Vargas Maria-Isabel52,Momjian Shahan62,Andrade-Lopes Stephanie1,Gubert Capucine7,Demarchi Marco Stefano8,Mainta Ismini9,Jornayvaz François R12,Samii Kaveh102,Stalder Grégoire1112,Leboulleux Sophie12

Affiliation:

1. Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

2. University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

3. Department of Internal Medicine, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Via Tesserete Lugano, Switzerland

4. Department of Pathology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

5. Department of Neuroradiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

6. Department of Neurosurgery, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

7. Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

8. Department of Thoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

9. Department of Nuclear Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

10. Department of Hematology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

11. Service and Central Laboratory of Hematology, Lausanne University Hospital, rue du Bugnon Lausanne, Switzerland.

12. Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland

Abstract

Langerhans cell histiocytosis (LCH) may present as unifocal disease of the suprasellar region, with symptoms and signs of hypopituitarism, arginine vasopressin deficiency (AVP-D), and weight gain. Transcranial biopsy is necessary to define diagnosis and guide treatment decisions, but it is associated with significant morbidity. We describe a patient with Hashimoto thyroiditis and a single hypothalamic mass in whom LCH diagnosis was made by thyroid fine-needle aspiration cytology (FNAC) performed despite nonspecific findings in thyroid imaging, on the basis of a slightly elevated [18F]-fluorodeoxyglucose (FDG) avidity on PET/CT and volume increase during follow-up.

Publisher

Bioscientifica

Reference24 articles.

1. Suprasellar masses: diagnosis and differential diagnosis;Hershey,1993

2. Incidental langerhans cell histiocytosis of thyroid: case report and review of the literature;Foulet-Roge,2002

3. Langerhans cell histiocytosis: diagnosis on thyroid aspirate and review of the literature;Saqi,2015

4. Fine needle aspiration cytology of Langerhans cell histiocytosis involving the thyroid: a case report;Kirchgraber,1994

5. Fine-needle aspiration cytology in a case of isolated involvement of thyroid with Langerhans cell histiocytosis;Sahoo,1998

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