Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Published:2019-08-13 Issue:13 Volume:134 Page:1084-1094
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Yun¹²,Chen Liguang¹,Yu Jian¹,Ghia Emanuela M.¹,Choi Michael Y.¹,Zhang Ling¹,Zhang Suping¹³^ORCID,Sanchez-Lopez Elsa⁴⁵^ORCID,Widhopf George F.¹,Messer Karen¹,Rassenti Laura Z.¹,Jamieson Catriona¹⁶,Kipps Thomas J.¹³^ORCID

Affiliation:

1. Moores Cancer Center, University of California, San Diego, La Jolla, CA;

2. Edmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China;

3. Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, Guangdong, China; and

4. Department of Pharmacology and

5. Department of Pathology, School of Medicine, and

6. Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA

Abstract

Key Points Nurse-like cells express Wnt5a to induce ROR1-dependent stimulation of NF-κB, which leads to autocrine IL-6-induced STAT3 activation in CLL cells. Cirmtuzumab inhibits Wnt5a-induced, ROR1-dependent stimulation of NF-κB, and thereby represses autocrine IL-6-dependent STAT3 activation in CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/13/1084/1223100/bloodbld2019001366.pdf

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