High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

Author:

Cui Bing12,Ghia Emanuela M.1,Chen Liguang1,Rassenti Laura Z.1,DeBoever Christopher3ORCID,Widhopf George F.1,Yu Jian1,Neuberg Donna S.4ORCID,Wierda William G.5,Rai Kanti R.6ORCID,Kay Neil E.7ORCID,Brown Jennifer R.8,Jones Jeffrey A.9,Gribben John G.10,Frazer Kelly A.11ORCID,Kipps Thomas J.1

Affiliation:

1. Department of Medicine, Moores Cancer Center, University of California, San Diego, San Diego, CA;

2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

3. Bioinformatics and Systems Biology, University of California, San Diego, San Diego, CA;

4. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, MA;

5. Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;

6. Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hempstead, NY;

7. Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN;

8. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, MA;

9. Division of Hematology and Comprehensive Cancer Center, The Ohio State University, Columbus, OH;

10. Department of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK; and

11. Moores Cancer Center, Department of Pediatrics and Rady Children's Hospital, Institute for Genomic Medicine, Chronic Lymphocytic Leukemia Research Consortium, University of California, San Diego, San Diego, CA

Abstract

Key Points The expression level of ROR1 on CLL cells varies between patients. High-level CLL-cell expression of ROR1 associates with more aggressive disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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