LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis-Reference-Cited by-同舟云学术

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

Published:2019-07-31 Issue:14 Volume:134 Page:1159-1175
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Morishima Tatsuya¹^ORCID,Krahl Ann-Christin¹,Nasri Masoud¹,Xu Yun¹,Aghaallaei Narges¹^ORCID,Findik Betül¹,Klimiankou Maksim¹,Ritter Malte¹,Hartmann Marcus D.²^ORCID,Gloeckner Christian Johannes³⁴^ORCID,Stefanczyk Sylwia¹^ORCID,Lindner Christian¹,Oswald Benedikt¹,Bernhard Regine¹,Hähnel Karin¹,Hermanutz-Klein Ursula¹,Ebinger Martin⁵,Handgretinger Rupert⁵,Casadei Nicolas⁶^ORCID,Welte Karl⁵,Andre Maya⁵⁷,Müller Patrick¹⁸^ORCID,Bajoghli Baubak¹^ORCID,Skokowa Julia¹^ORCID

Affiliation:

1. Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Germany;

2. Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany;

3. German Center for Neurodegenerative Diseases, Tübingen, Germany;

4. Center for Ophthalmology, Institute for Ophthalmic Research, University Hospital Tübingen, Tübingen, Germany;

5. University Children's Hospital Tübingen, Tübingen, Germany;

6. Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany;

7. Department of Pediatric Intensive Care, University of Basel Children’s Hospital, Basel, Switzerland; and

8. Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany

Abstract

Key Points LMO2 is deacetylated by the NAMPT/SIRT2 pathway. LMO2 deacetylation is essential for LIM domain binding 1 binding and TAL1 complex activation during hematopoiesis and T-ALL leukemogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/14/1159/1223081/bloodbld2019000095.pdf

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