Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis-Reference-Cited by-同舟云学术

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis

Published:2014-04-03 Issue:14 Volume:123 Page:2229-2237
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Skokowa Julia¹,Steinemann Doris²,Katsman-Kuipers Jenny E.³,Zeidler Cornelia¹,Klimenkova Olga¹,Klimiankou Maksim¹,Ünalan Murat¹,Kandabarau Siarhei¹,Makaryan Vahagn⁴,Beekman Renee⁵,Behrens Kira⁶,Stocking Carol⁶,Obenauer Julia³⁵,Schnittger Susanne⁷,Kohlmann Alexander⁷,Valkhof Marijke G.⁵,Hoogenboezem Remco⁵,Göhring Gudrun²,Reinhardt Dirk⁸,Schlegelberger Brigitte²,Stanulla Martin⁸,Vandenberghe Peter⁹,Donadieu Jean¹⁰,Zwaan C. Michel³¹¹,Touw Ivo P.⁵,van den Heuvel-Eibrink Marry M.³¹¹,Dale David C.⁴,Welte Karl¹

Affiliation:

1. Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany;

2. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany;

3. Pediatric Oncology/Hematology, Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands;

4. University of Washington, Seattle, WA;

5. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

6. Heinrich-Pette-Institute, Hamburg, Germany;

7. Munich Leukemia Laboratory, Munich, Germany;

8. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;

9. Center for Human Genetics, Katholieke Universiteit Leuven/University Hospital Leuven, Leuven, Belgium;

10. Service d'Hémato-Oncologie Pédiatrique, Hopital Trousseau, Paris, France; and

11. Dutch Childhood Oncology Group, The Hague, The Netherlands

Abstract

Key Points CN/AML patients have a high frequency of CSF3R and RUNX1 mutations. CSF3R and RUNX1 mutations induce elevated proliferation of CD34+ cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/14/2229/1375469/2229.pdf

Reference44 articles.

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