IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL

Author:

Simonin Mathieu123,Lhermitte Ludovic13,Dourthe Marie-Emilie134,Lengliné Etienne5,Graux Carlos6,Grardel Nathalie7ORCID,Cayuela Jean-Michel8,Arnoux Isabelle9,Gandemer Virginie10,Ifrah Norbert11ORCID,Dombret Hervé5,Baruchel André4,Macintyre Elizabeth13,Petit Arnaud212ORCID,Boissel Nicolas5,Asnafi Vahid13

Affiliation:

1. Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Université de Paris, Paris, France;

2. Department of Pediatric Hematology and Oncology, AP-HP, Armand Trousseau Hospital, Sorbonne Université, Paris, France;

3. Institut Necker-Enfants Malades (INEM), INSERM U1151, Paris, France;

4. Department of Pediatric Hematology and Immunology, Robert Debré Hospital, AP-HP, University Paris Diderot, Paris, France;

5. Université Paris Diderot, Institut Universitaire d’Hématologie, EA-3518, AP-HP, University Hospital Saint-Louis, Paris, France;

6. Department of Hematology, Université Catholique de Louvain, CHU UCL Namur-site Godinne, Yvoir, Belgium;

7. Laboratory of Hematology, Centre Hospitalier Régional Universitaire (CHRU) Lille, Lille, France, and U1172, INSERM, Lille, France;

8. Laboratory of Hematology and EA 3518 University Hospital Saint-Louis, AP-HP, Université de Paris;

9. Hematology Laboratory, Marseille University Hospital Timone, Marseille, France;

10. Department of Pediatric Hematology and Oncology, University Hospital of Rennes, Rennes, France;

11. PRES LUNAM (Pôle de Recherche et d’Enseignement Supérieur–l’Université Nantes Angers Le Mans), Centre Hospitalier Universitaire (CHU) Angers Service des Maladies du Sang, INSERM U892, Angers, France; and

12. Université Pierre et Marie Currie Université Paris 06, Unité Mixte de Recherche en Santé (UMRS) 938, Centre de Recherche (CDR) Saint Antoine GRC n°07, GRC MyPAC (Groupe de Recherche Clinique sur les Myéloproliferations Aiguës et Chroniques), Paris, France

Abstract

Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions and mutations in the gene encoding the transcription factor IKAROS among 1260 children and adults with immature T-ALL/LBL, defining its frequency and, importantly, its association with poor outcome in multivariate models. Pathogenic alterations in IKZF1 now can be added to minimal residual disease detection and the established 4-gene oncogenetic classifier to better predict poor outcomes of T-ALL/LBL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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