Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

Author:

Petit Arnaud12ORCID,Trinquand Amélie34,Chevret Sylvie5,Ballerini Paola6,Cayuela Jean-Michel7,Grardel Nathalie8,Touzart Aurore34,Brethon Benoit9,Lapillonne Hélène26,Schmitt Claudine10,Thouvenin Sandrine11,Michel Gerard1213,Preudhomme Claude814,Soulier Jean15,Landman-Parker Judith12,Leverger Guy12,Macintyre Elizabeth34,Baruchel André9,Asnafi Vahid34

Affiliation:

1. Department of Pediatric Hematology and Oncology, Assistance Publique–Hôpitaux de Paris (AP-HP), Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), Armand Trousseau Hospital, Paris, France;

2. Sorbonne Universités, UPMC Univ Paris 06, Unité Mixte de Recherche (UMR) S938, CDR Saint-Antoine, Groupe de Recherche Clinique (GRC) 07, GRC MyPAC, Paris, France;

3. Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades, INSERM U1151, Paris, France;

4. Laboratory of Onco-Hematology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France;

5. INSERM UMRS 1153, Université Paris Diderot, Sorbonne Paris Cité, Paris, France;

6. Laboratory of Hematology, AP-HP, GH HUEP, Armand Trousseau Hospital, Paris, France;

7. Laboratory of Hematology, Saint-Louis Hospital, AP-HP, Paris, France;

8. Laboratory of Hematology, Centre Hospitalier Régional Universitaire de Lille, Lille, France;

9. Department of Pediatric Hematology and Immunology, Robert Debré Hospital, AP-HP, Paris, France;

10. Department of Pediatric Onco-hematology, Centre Hospitalier Universitaire (CHU) de Nancy, Nancy, France;

11. Department of Pediatric Onco-hematology, CHU de Saint-Etienne, Saint-Etienne, France;

12. Department of Pediatric Hematology and Oncology, Timone Hospital, Marseilles, France;

13. Research Unit EA 3279, Aix-Marseille University, Marseilles, France;

14. U1172, INSERM, Lille, France; and

15. Department of Cytogenetics, Saint-Louis Hospital, AP-HP, Paris, France

Abstract

Key Points In pediatric T-ALL, oncogenetic markers, MRD, and WBC count are independent predictors of outcome. These factors should be used together for individual treatment stratification.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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