AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics-Reference-Cited by-同舟云学术

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

Published:2016-02-22 Issue:4 Volume:50 Page:1109-1123
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Eketjäll Susanna¹²,Janson Juliette¹²,Kaspersson Karin³,Bogstedt Anna¹²,Jeppsson Fredrik⁴⁵,Fälting Johanna⁴,Haeberlein Samantha Budd⁶,Kugler Alan R.⁶,Alexander Robert C.⁶,Cebers Gvido⁶

Affiliation:

1. AstraZeneca Translational Sciences Centre, Science for Life Laboratory, Personal Healthcare and Biomarkers, AstraZeneca, Solna, Sweden

2. Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden

3. Discovery Science iMed, AstraZeneca, Mölndal, Sweden

4. CNS and Pain iMed, AstraZeneca, Södertälje, Sweden

5. Operations Global Quality, AstraZeneca, Södertälje, Sweden

6. Neuroscience iMed, IMED Biotech Unit, AstraZeneca, Cambridge, MA, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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4. Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE;Vassar;Science,1999

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