Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in Midlife: A Cross-Sectional Study-Reference-Cited by-同舟云学术

Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in Midlife: A Cross-Sectional Study

Published:2023-09-19 Issue:1 Volume:7 Page:1025-1031
ISSN:2542-4823
Container-title:Journal of Alzheimer's Disease Reports
language:
Short-container-title:ADR

Author:

Franks Katherine H.¹,Cribb Lachlan¹,Bransby Lisa¹,Buckley Rachel²³⁴,Yassi Nawaf⁵⁶,Chong Trevor T.-J.¹⁷⁸,Lim Yen Ying¹,Pase Matthew P.¹⁹

Affiliation:

1. Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia

2. Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia

3. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

4. Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Boston, MA, USA

5. Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia

6. Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

7. Department of Neurology, Alfred Health, Melbourne, Victoria, Australia

8. Department of Clinical Neurosciences, St. Vincent’s Hospital, Melbourne, Victoria, Australia

9. Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA

Abstract

Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen’s f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

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