Multiple Neurodegenerative Pathologies in an Alzheimer’s Disease Patient Treated with Fornical Deep Brain Stimulation-Reference-Cited by-同舟云学术

Multiple Neurodegenerative Pathologies in an Alzheimer’s Disease Patient Treated with Fornical Deep Brain Stimulation

Published:2021-04-20 Issue:4 Volume:80 Page:1383-1387
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

White Bartholomew¹²,Lyketsos Constantine G.³,Rosenberg Paul B.³,Oh Esther S.³⁴,Chen Liam¹⁵

Affiliation:

1. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA

2. Current affiliation: Department of Pathology, Emory School of Medicine, Atlanta, GA, USA

3. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA

4. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA

5. Current affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA

Abstract

As an established treatment for movement disorders, deep brain stimulation (DBS) has been adapted for the treatment of Alzheimer’s disease (AD) by modulating fornix activity. Although it is generally regarded as a safe intervention in patients over 65 years of age, the complex neurophysiology and interconnection within circuits connected to the fornix warrants a careful ongoing evaluation of the true benefit and risk potential of DBS on slowing cognitive decline in AD patients. Here we report on a patient who died long after being implanted with a DBS device who donated her brain for neuropathologic study. The autopsy confirmed multiple proteinopathies including AD-related change, diffuse neocortical Lewy body disease, TDP-43 proteinopathy, and a nonspecific tauopathy. We discuss the possible mechanisms of these overlapping neurodegenerative disorders and caution that future studies of DBS for AD will need to take these findings into consideration.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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