White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia-Reference-Cited by-同舟云学术

White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia

Published:2023-07-18 Issue:2 Volume:94 Page:695-707
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Edwards Lauren¹,Thomas Kelsey R.²³,Weigand Alexandra J.¹,Edmonds Emily C.⁴⁵,Clark Alexandra L.⁶,Walker Kayla S.⁷,Brenner Einat K.³,Nation Daniel A.⁸,Maillard Pauline⁹,Bondi Mark W.³¹⁰,Bangen Katherine J.²³,

Affiliation:

1. San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA

2. Research Service, VA San Diego Healthcare System, San Diego, CA, USA

3. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA

4. Banner Alzheimer’s Institute, Tucson, AZ, USA

5. Department of Psychology, University of Arizona, Tucson, AZ, USA

6. Department of Psychology, University of Texas at Austin, Austin, TX, USA

7. San Diego State University, San Diego, CA, USA

8. Department of Psychology, University of California Irvine, Irvine, CA, USA

9. Department of Neurology, University of California, Davis, Davis, CA, USA

10. Psychology Service, VA San Diego Healthcare System, San Diego, CA, USA

Abstract

Background: Alzheimer’s disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear. Objective: To examine whether white matter hyperintensity (WMH) volume moderates the independent association between each AD biomarker and cognition. Methods: In 586 older adults without dementia, linear regressions tested the interaction between amyloid-β (Aβ) positron emission tomography (PET) and WMH volume on cognition, independent of tau-PET. We also tested the interaction between tau-PET and WMH volume on cognition, independent of Aβ-PET. Results: Adjusting for tau-PET, the quadratic effect of WMH interacted with Aβ-PET to impact memory. There was no interaction between either the linear or quadratic effect of WMH and Aβ-PET on executive function. There was no interaction between WMH volume and tau-PET on either cognitive measure. Conclusion: Results suggest that cerebrovascular lesions act synergistically with Aβ to affect memory, independent of tau, highlighting the importance of incorporating vascular pathology into biomarker assessment of AD.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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