Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

Author:

Brier Matthew R.1,Gordon Brian23,Friedrichsen Karl2,McCarthy John4,Stern Ari4,Christensen Jon2,Owen Christopher2,Aldea Patricia2,Su Yi2,Hassenstab Jason13,Cairns Nigel J.135,Holtzman David M.136,Fagan Anne M.136,Morris John C.1356,Benzinger Tammie L. S.237,Ances Beau M.1236

Affiliation:

1. Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.

2. Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA.

3. Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, St. Louis, MO 63110, USA.

4. Department of Mathematics, Washington University in St. Louis, St. Louis, MO 63110, USA.

5. Department of Pathology, Washington University in St. Louis, St. Louis, MO 63110, USA.

6. Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO 63110, USA.

7. Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO 63110, USA.

Abstract

PET imaging of pathological tau correlates more closely with Alzheimer’s disease–related cognitive impairment than does imaging of β-amyloid.

Funder

NIH

NSF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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