Now is the Time to Improve Cognitive Screening and Assessment for Clinical and Research Advancement

Author:

Ashford J. Wesson123,Schmitt Frederick A.34,Bergeron Michael F.5,Bayley Peter J.123,Clifford James O.6,Xu Qun7,Liu Xiaolei89,Zhou Xianbo1011,Kumar Vinod12,Buschke Herman313,Dean Margaret314,Finkel Sanford I.315,Hyer Lee316,Perry George317

Affiliation:

1. War Related Illness and Injury Study Center, VA Palo Alto HCS, Palo Alto, CA, USA

2. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

3. Medical, Scientific, Memory Screening Advisory Board, Alzheimer’s Foundation of American (AFA), New York, USA

4. Departments of Neurology, Psychiatry, Neurosurgery, Psychology, Behavioral Science; Sanders-Brown Center on Aging, Spinal Cord & Brain Injury Research Center, University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA

5. SIVOTEC Analytics, Boca Raton, FL, USA

6. College of San Mateo, San Mateo, CA, USA

7. Health Management Center, Department of Neurology, Renji Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China

8. Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

9. Yunnan Provincial Clinical Research Center for Neurological Diseases, Yunnan, China

10. Center for Alzheimer’s Research, Washington Institute of Clinical Research, Vienna, VA, USA

11. Zhongze Therapeutics, Shanghai, China

12. University of Illinois, Chicago, IL, USA

13. The Saul R. Korey Department of Neurology and Dominick P. Purpura Department of Neuroscience, Lena and Joseph Gluck Distinguished Scholar in Neurology, Albert Einstein College of Medicine, Bronx, NY, USA

14. Geriatric Division, Internal Medicine, Texas Tech Health Sciences Center, Amarillo, TX, USA

15. University of Chicago Medical School, Chicago, IL, USA

16. Gateway Behavioral Health, Mercer University, School of Medicine, Savannah, GA, USA

17. Brain Health Consortium, Department Biology and Chemistry, University of Texas at San Antonio, San Antonio, TX, USA

Abstract

Wang et al. analyze Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment accuracy as screening tests for detecting dementia associated with Alzheimer’s disease (AD). Such tests are at the center of controversy regarding recognition and treatment of AD. The continued widespread use of tools such as MMSE (1975) underscores the failure of advancing cognitive screening and assessment, which has hampered the development and evaluation of AD treatments. It is time to employ readily available, efficient computerized measures for population/mass screening, clinical assessment of dementia progression, and accurate determination of approaches for prevention and treatment of AD and related conditions.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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