CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat Hippocampal Neurons

Author:

Quan Qiankun123,Qian Yihua23,Li Xi1,Li Ming1

Affiliation:

1. Department of Geriatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

2. Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China

3. Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, Xi’an Jiaotong University Health Science Center, Xi’an, China

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference56 articles.

1. 2018 Alzheimer’s disease facts and figures;Alzheimer’s Association;Alzheimers Dement,2018

2. Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer’s disease;Barage;Neuropeptides,2015

3. Limited activation of the intrinsic apoptotic pathway plays a main role in amyloid-β-induced apoptosis without eliciting the activation of the extrinsic apoptotic pathway;Islam;Int J Mol Med,2017

4. Amyloid-β and tau: The trigger and bullet in Alzheimer disease pathogenesis;Bloom;JAMA Neurol,2014

5. Synaptic plasticity, dementia and Alzheimer disease;Skaper;CNS Neurol Disord Drug Targets,2017

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