Effect and mechanism of mirror therapy on lower limb rehabilitation after ischemic stroke: A fMRI study
-
Published:2022-08-16
Issue:1
Volume:51
Page:65-77
-
ISSN:1053-8135
-
Container-title:NeuroRehabilitation
-
language:
-
Short-container-title:NRE
Author:
Cui Wei1, Huang Lin1, Tian Yang1, Luo Hong1, Chen Shuang1, Yang Yan1, Li Yamei1, Fu Jing1, Yu Qian1, Xu Li1
Affiliation:
1. Department of Rehabilitation Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Sichuan, China
Abstract
BACKGROUND: Mirror therapy has been gradually adopted for lower limb rehabilitation, but its efficacy and neural mechanism are not well understood. OBJECTIVE: This study aims to investigate the effect and neural mechanism of mirror therapy on lower limb rehabilitation after ischemic stroke by using resting state functional magnetic resonance imaging (rs-fMRI). METHODS: A single-blind and randomized controlled pilot study was conducted. 32 patients with ischemic stroke were included in this study and randomly divided into two groups – the control group (CT, n = 16) and the mirror therapy group (MT, n = 16). Both the CT and MT groups received medication and routine rehabilitation training. In addition, mirror therapy was added to the MT group 5 times a week for 30 minutes each time over a period of 3 weeks. Patients’ motor functions, functional connectivity (FC), regional homogeneity (ReHo), and fractional amplitude of low-frequency fluctuations (fALFF) were analyzed both before and immediately after the treatment. RESULTS: Patients’ motor functions showed significant improvement in both groups compared to those before treatment (p < 0.01). Moreover, the MT group showed significantly better improvement than the CT group after the treatment (p < 0.05). FC, ReHo and fALFF indicated enhanced neuronal activities in motor function-related brain regions in the MT group compared to the CT group. CONCLUSION: Mirror therapy promotes the recovery of lower limb motor functions in patients with ischemic stroke. Through the comparative rs-fMRI analysis, it is found that the mirror therapy promotes the functional reorganization of the injured brain.
Subject
Neurology (clinical),Rehabilitation,Physical Therapy, Sports Therapy and Rehabilitation
Reference52 articles.
1. A, G. L., & A, G. D. (2018) The cross education of strength and skill following unilateral strength training in the upper and lower limbs, Journal of Neurophysiology 120(2). 2. A, S. J., & Phillips, S. M. E. (2003) Using motor imagery in the rehabilitation of hemiparesis, Archives of Physical Medicine and Rehabilitation 84(7). 3. Aliyeh, D. , Mokhtar, A. , & Gholamreza, A. (2018) Effect of different designs of ankle-foot orthoses on gait in patients with stroke: A systematic review, Gait & Posture 62. 4. Altschuler, E. L. , Wisdom, S. B. , Stone, L. , Foster, C. , Galasko, D. , Llewellyn, D. M. E. , & Ramachandran, V. (1999) Rehabilitation of hemiparesis after stroke with a mirror, The Lancet 353(9169). 5. Effect of activity-based mirror therapy on lower limb motor-recovery and gait in stroke: A randomised controlled trial;Arya,;Neuropsychological Rehabilitation,2019
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|