Breast cancer detection using Histopathology Image with Mini-Batch Stochastic Gradient Descent and Convolutional Neural Network

Abstract

Cancer is a devastating disease that has far-reaching effects on our culture and economy, in addition to the human lives it takes. Regarding budgetary responsibility, investing just in cancer treatment is not an option. Early diagnosis is a crucial part of the remedy that sometimes gets overlooked. Malignancy is often diagnosed and evaluated using Histopathology Images (HI), which are widely accepted as the gold standard in the field. Yet, even for experienced pathologists, analysing such images is challenging, which raises concerns of inter- and intra-observer variability. The analysis also requires a substantial investment of time and energy. One way that such an examination may be sped up is by making use of computer-assisted diagnostics devices. The purpose of this research is to create a comprehensive cancer detection system using images of breast and prostate histopathology stained with haematoxylin and eosin (H&E). Proposed here is work on improving colour normalisation methods, constructing an integrated model for nuclei segmentation and multiple objects overlap resolution, introducing and evaluating multi-level features for extracting relevant histopathological image and interpretable information, and developing classification algorithms for tasks such as cancer diagnosis, tumor identification, and tumor class labelling. Mini-Batch Stochastic Gradient Descent and Convolutional Neural Network which obtained statistical kappa value for breast cancer histopathology images shows a high degree of consistency in the classification task, with a range of 0.610.80 for benign and low grades and a range of 0.811.0 for medium and high rates. The Support Vector Machine (SVM), on the other hand, shows an almost perfect degree of consistency (0.811.0) across the several breast cancer picture classifications (benign, low, medium, and high).