Timing and Reporting of Secondary Overall Survival End Points for Phase III Trials in Advanced/Metastatic Disease
Author:
Affiliation:
1. Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD
2. Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD
Abstract
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
https://ascopubs.org/doi/pdfdirect/10.1200/JCO.23.00413
Reference32 articles.
1. Evolution of the Randomized Clinical Trial in the Era of Precision Oncology
2. Survival Is Not a Good Outcome for Randomized Trials With Effective Subsequent Therapies
3. Overall Survival As the Outcome for Randomized Clinical Trials With Effective Subsequent Therapies
4. Progression-Free Survival: Meaningful or Simply Measurable?
5. Combining drugs and extending treatment — a PFS end point is not sufficient
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