Gastrointestinal and Hepatic Toxicities of Checkpoint Inhibitors: Algorithms for Management

Author:

Grover Shilpa1,Rahma Osama E.1,Hashemi Nikroo1,Lim Ramona M.1

Affiliation:

1. From the Harvard Medical School, Boston, MA; Brigham and Women’s Hospital, Boston, MA; Dana-Farber Cancer Institute, Brookline, MA.

Abstract

Gastrointestinal toxicities are among the leading causes of immune-related adverse effects of checkpoint blockade. These adverse events can be severe enough to require interruption or withdrawal of immune checkpoint blockade therapy. Patients with immune-related adverse effects require early recognition with an evaluation to rule out alternative etiologies and effective management to minimize complications. This article reviews the gastrointestinal and hepatic toxicities of the antibodies that target immune checkpoints CTLA-4 and PD-1/PD-L1 and provides an approach to their diagnosis and management.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

General Medicine

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