Prospective Clinical Trials to Advance the Study of Immune Checkpoint Inhibitor Toxicity

Author:

Cluxton Christopher12,Naidoo Jarushka123

Affiliation:

1. Beaumont Hospital, RCSI Cancer Centre, D09 V2N0 Dublin, Ireland

2. Department of Medicine, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland

3. Sidney Kimmel Comprehensive Cancer Center at John Hopkins University, Baltimore, MD 21218, USA

Abstract

Immune checkpoint inhibitors (ICIs) are a class of drug that produces durable and sustained anti-tumour responses in a wide variety of malignancies. The exponential rise in their use has been mirrored by a rise in immune-related adverse events (IrAEs). Knowledge of such toxicities, as well as effective management algorithms for these toxicities, is essential to optimize clinical efficacy and safety. Currently, the guidelines for management of the IrAEs are based largely on retrospective studies and case series. In this article, we review the current landscape of clinical trials investigating the management of IrAEs with an aim to develop standardised, randomised controlled trial-based management algorithms for ICI-related toxicities.

Publisher

MDPI AG

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