Irinotecan Dosing: Does the CPT in CPT-11 Stand for “Can’t Predict Toxicity”?
Author:
Affiliation:
1. Committee on Clinical Pharmacology, Cancer Research Center, The University of Chicago, Chicago, IL
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2002.20.1.7
Reference21 articles.
1. Phase I and pharmacokinetic trial of weekly CPT-11.
2. Bleiberg H, Cvitkovic E: Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: The European perspective. Eur J Cancer 32A: S18,1996-S23,
3. Recommended guidelines for the treatment of chemotherapy-induced diarrhea.
4. Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer
5. Humerickhouse R, Lohrbach K, Li L, et al: Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res 60: 1189,2000-1192,
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