The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.

Author:

Hyman David Michael1,Laetsch Theodore Willis2,Kummar Shivaani3,DuBois Steven G.4,Farago Anna F.5,Pappo Alberto S.6,Demetri George D.7,El-Deiry Wafik S.8,Lassen Ulrik Niels9,Dowlati Afshin10,Brose Marcia S.11,Boni Valentina12,Turpin Brian13,Nagasubramanian Ramamoorthy14,Cruickshank Scott15,Cox Michael Craig16,Ku Nora C.16,Hawkins Douglas S.17,Hong David S.18,Drilon Alexander E.19

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY;

2. University of Texas Southwestern, Dallas, TX;

3. Department of Medicine–Oncology, Palo Alto, CA;

4. Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Boston, MA;

5. Massachusetts General Hospital, Boston, MA;

6. St. Jude Children's Research Hospital, Memphis, TN;

7. Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA;

8. Fox Chase Cancer Center, Philadelphia, PA;

9. Rigshospitalet, Copenhagen, Denmark;

10. UH Cleveland Medical Center, Cleveland, OH;

11. Department of Otorhinolaryngology: Head and Neck Surgery, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA;

12. START Madrid CIOCC, Hospital HM Universitario Sanchinarro, Madrid, Spain;

13. Cincinnati Children's Hospital Medical Center, Cincinnati, OH;

14. Nemour's Children's Hospital, Orlando, FL;

15. Scott Cruickshank and Associates, Santa Barbara, CA;

16. Loxo Oncology, Inc., San Francisco, CA;

17. Seattle Children’s Hospital, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA;

18. The University of Texas MD Anderson Cancer Center, Houston, TX;

19. Memorial Sloan-Kettering Cancer Center, New York, NY;

Abstract

LBA2501 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, June 3, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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