Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata-Reference-Cited by-同舟云学术

Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata

Published:2020 Issue:40 Volume:10 Page:23566-23572
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Juan¹²³⁴,Ding Ning¹²³⁴,Wu Yun¹²³⁴,Shi Xiaoping¹²³⁴,Qi Bowen¹²³⁴,Liu Xiao¹²³⁴^ORCID,Wang Xiaohui¹²³⁴,Li Jun¹²³⁴,Tu Pengfei¹²³⁴,Shi Shepo¹²³⁴^ORCID

Affiliation:

1. Modern Research Center for Traditional Chinese Medicine

2. Beijing University of Chinese Medicine

3. Beijing 100029

4. China

Abstract

One-pot enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds was developed by integrating three enzymes PcPCL, AtMatB, and HsPKS3.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA04133E

Reference64 articles.

1. Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M1 Allosteric Muscarinic Receptor Modulators

2. Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M1 Positive Allosteric Modulators

3. The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors

4. Isothiazolopyridones: Synthesis, Structure, and Biological Activity of a New Class of Antibacterial Agents

5. A Study of Some Quinolizone Derivatives

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