Synthesis and conformational analysis of vicinally branched trisaccharide β-d-Galf-(1 → 2)-[β-d-Galf-(1 → 3)-]-α-Galp from Cryptococcus neoformans galactoxylomannan-Reference-Cited by-同舟云学术

Synthesis and conformational analysis of vicinally branched trisaccharide β-d-Galf-(1 → 2)-[β-d-Galf-(1 → 3)-]-α-Galp from Cryptococcus neoformans galactoxylomannan

Published:2021 Issue:13 Volume:19 Page:2923-2931
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Dorokhova Vera S.¹²³⁴⁵,Gerbst Alexey G.¹²³⁴⁵,Komarova Bozhena S.¹²³⁴⁵,Previato José O.⁶⁷⁸⁹¹⁰,Previato Lúcia Mendonça⁶⁷⁸⁹¹⁰,Dmitrenok Andrey S.¹²³⁴⁵,Shashkov Alexander S.¹²³⁴⁵,Krylov Vadim B.¹²³⁴⁵,Nifantiev Nikolay E.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Glycoconjugate Chemistry

2. N.D. Zelinsky Institute of Organic Chemistry

3. Russian Academy of Sciences

4. 119991 Moscow

5. Russia

6. Laboratório de Glicobiologia

7. Instituto de Biofísica Carlos Chagas Filho

8. Universidade Federal do Rio de Janeiro

9. Rio de Janeiro

10. Brazil

Abstract

Two disaccharides and one trisaccharide related to the galactoxylomannan (GalXMan) of Cryptococcus neoformans were synthesized for the first time. Their conformational behavior was studied using computer calculations along with NMR analysis.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02071K

Reference50 articles.

1. Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans

2. Unusual Galactofuranose Modification of a Capsule Polysaccharide in the Pathogenic Yeast Cryptococcus neoformans

3. A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes

4. Synthesis and immunological studies of glycoconjugates of Cryptococcus neoformans capsular glucuronoxylomannan oligosaccharide structures

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