A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes-Reference-Cited by-同舟云学术

A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes

Published:2020 Issue:34 Volume:11 Page:9209-9217
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guazzelli Lorenzo¹²³⁴⁵^ORCID,Crawford Conor J.¹²³⁴⁵^ORCID,Ulc Rebecca¹²³⁴⁵,Bowen Anthony⁶⁷⁸⁹¹⁰^ORCID,McCabe Orla¹²³⁴⁵,Jedlicka Anne J.⁶⁷⁸⁹¹⁰,Wear Maggie P.⁶⁷⁸⁹¹⁰,Casadevall Arturo⁶⁷⁸⁹¹⁰^ORCID,Oscarson Stefan¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Synthesis and Chemical Biology

2. UCD School of Chemistry

3. University College Dublin

4. Dublin 4

5. Ireland

6. Department of Molecular Microbiology and Immunology

7. Johns Hopkins Bloomberg School of Public Health

8. The Johns Hopkins University

9. Baltimore

10. USA

Abstract

A library of Cryptococcus neoformans glucuronoxylomannan (GXM) oligosaccharides was synthesized using a thioglycoside building block strategy. The first GXM microarray was printed, allowing mapping of epitopes of antibodies directed towards GXM.

Funder

Irish Research Council

FP7 People: Marie-Curie Actions

Science Foundation Ireland

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01249A

Reference43 articles.