Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F
Author:
Affiliation:
1. Department of Biomolecular Systems
2. Max Planck Institute of Colloids and Interfaces
3. D-14424 Potsdam
4. Germany
5. Department of Chemistry and Biochemistry
6. Freie Universität Berlin
7. D-14195 Berlin
Abstract
Chimeric antigens are an attractive means to induce an immune response against multiple bacterial serotypes. The chimeric semisynthetic glycoconjugate ST19AF induced antibodies with opsonic activity able to kill ST19A and ST19F bacteria in rabbits.
Funder
Max-Planck-Gesellschaft
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02230F
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