Author:
Micoli Francesca,Romano Maria Rosaria,Carboni Filippo,Adamo Roberto,Berti Francesco
Abstract
AbstractMultivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the last 22 years. The use of polysaccharide-protein conjugate vaccines has been pivotal in reducing the incidence of invasive pneumococcal disease despite the emergence of non-vaccine serotypes. Notwithstanding its undoubtable success, some weaknesses have called for continuous improvement of pneumococcal vaccination. For instance, despite their inclusion in pneumococcal conjugate vaccines, there are challenges associated with some serotypes. In particular, Streptococcus pneumoniae type 3 remains a major cause of invasive pneumococcal disease in several countries.Here a deep revision of the strengths and weaknesses of the licensed pneumococcal conjugate vaccines and other vaccine candidates currently in clinical development is reported.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference92 articles.
1. Centers for Disease Control and Prevention: Epidemiology and Prevention of vaccine-preventablediseases, 13th edn. Public Health Foundation, Washington, DC, USA (2015)
2. Mitchell, A.M., Mitchell, T.J.: Streptococcus pneumoniae: virulence factors and variation. Clin. Microbiol. Infect. 16, 411–418 (2010)
3. Geno, K.A., Gilbert, G.L., Song, J.Y., Skovsted, I.C., Klugman, K.P., Jones, C., Konradsen, H.B., Nahm, M.H.: Pneumococcal capsules and their types: past, present, and future. Clin. Microbiol. Rev. 28, 871–899 (2015). )
4. Paton, J.C., Trappetti, C.: Streptococcus pneumoniae capsular polysaccharide. Microbiol. Spec. 7 (2019). https://doi.org/10.1128/microbiolspec.GPP3-0019-2018
5. Ganaie, F., Saad, J.S., McGee, L., van Tonder, A.J., Bentley, S.D., Lo, S.W., Gladstone, R.A., Turner, P., Keenan, J.D., Breiman, R.F., et al.: A new pneumococcal capsule type, 10D, is the 100th serotype and has a large cps fragment from an oral Streptococcus. mBio. 11 (2020). https://doi.org/10.1128/mBio.00937-20
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献