Chlorogenic acid inhibits trimethylamine-N-oxide formation and remodels intestinal microbiota to alleviate liver dysfunction in high l-carnitine feeding mice-Reference-Cited by-同舟云学术

Chlorogenic acid inhibits trimethylamine-N-oxide formation and remodels intestinal microbiota to alleviate liver dysfunction in high l-carnitine feeding mice

Published:2021 Issue:21 Volume:12 Page:10500-10511
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Xiangnan¹,Shi Lin¹,Chen Rui²,Zhao Yan²,Ren Daoyuan¹^ORCID,Yang Xingbin¹^ORCID

Affiliation:

1. Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China

2. Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China

Abstract

Chlorogenic acid alleviates liver dysfunction in l-carnitine feeding mice via inhibiting trimethylamine-N-oxide (TMAO) formation and reconstructing the intestinal microbiota.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO01778K

Reference41 articles.

1. L-carnitine contributes to enhancement of neurogenesis from mesenchymal stem cells through Wnt/β-catenin and PKA pathway

2. Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study

3. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis