Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A-Reference-Cited by-同舟云学术

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

Published:2020 Issue:10 Volume:11 Page:2670-2680
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Juárez-Jiménez Jordi¹²³⁴^ORCID,Gupta Arun A.¹²³⁴,Karunanithy Gogulan⁵⁶⁷⁴^ORCID,Mey Antonia S. J. S.¹²³⁴^ORCID,Georgiou Charis¹²³⁴,Ioannidis Harris¹²³⁴^ORCID,De Simone Alessio¹²³⁴,Barlow Paul N.¹²³⁴,Hulme Alison N.¹²³⁴^ORCID,Walkinshaw Malcolm D.⁸³⁴^ORCID,Baldwin Andrew J.⁵⁶⁷⁴^ORCID,Michel Julien¹²³⁴^ORCID

Affiliation:

1. EaStCHEM School of Chemistry

2. University of Edinburgh

3. Edinburgh

4. UK

5. Department of Chemistry, Physical and Theoretical Chemistry Laboratory

6. University of Oxford

7. Oxford

8. School of Biological Sciences

Abstract

Molecular simulations were used to design large scale loop motions in the enzyme cyclophilin A and NMR and biophysical methods were employed to validate the models.

Funder

Diamond Light Source

European Commission

Engineering and Physical Sciences Research Council

Wellcome Trust

FP7 Ideas: European Research Council

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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