Interaction mechanism exploration of HEA derivatives as BACE1 inhibitors by in silico analysis-Reference-Cited by-同舟云学术

Interaction mechanism exploration of HEA derivatives as BACE1 inhibitors by in silico analysis

Published:2016 Issue:4 Volume:12 Page:1151-1165
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Wu Qian¹²³⁴⁵,Li Xianguo¹²³⁴⁵,Gao Qingping⁶⁷⁸⁵,Wang Jinghui⁹¹⁰¹¹⁵,Li Yan⁹¹⁰¹¹⁵,Yang Ling¹²¹³¹⁴¹¹⁵

Affiliation:

1. Key Laboratory of Marine Chemistry Theory and Technology

2. Ministry of Education

3. Ocean University of China

4. Qingdao

5. China

6. School of Chemical Engineering

7. Weifang Vocational College

8. Weifang

9. Department of Materials Science and Chemical Engineering

10. Dalian University of Technology

11. Dalian

12. Lab of Pharmaceutical Resource Discovery

13. Dalian Institute of Chemical Physics

14. Graduate School of the Chinese Academy of Sciences

Abstract

The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates the generation of β-amyloid (Aβ) peptides which play a critical early role in the pathogenesis of Alzheimer's disease (AD), and thus it is a prime target for lowering the Aβ levels to treat AD.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C5MB00859J

Reference69 articles.

1. Alzheimer's Disease--Genotypes, Phenotype, and Treatments

2. Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems

3. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE