A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation-Reference-Cited by-同舟云学术

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A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation

Published:2018 Issue:35 Volume:16 Page:6537-6542
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yamamoto Masashi¹²³⁴,Shinoda Kiyomichi¹²³⁴,Ni Jizhi¹²³⁴⁵^ORCID,Sasaki Daisuke¹²³⁴⁵,Kanai Motomu¹²³⁴⁵^ORCID,Sohma Youhei¹²³⁴⁵^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. The University of Tokyo

3. Tokyo 113-0033

4. Japan

5. JST-ERATO

Abstract

A stable Aβ oligomer mimic that is transformed into fibrils by a chemical stimulus, i.e., an oxime exchange reaction, is disclosed.

Funder

Exploratory Research for Advanced Technology

Japan Society for the Promotion of Science

Tokyo Biochemical Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01875H

Reference32 articles.

1. Protein Misfolding, Functional Amyloid, and Human Disease

2. Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

3. Structure-neurotoxicity relationships of amyloid -protein oligomers

4. Stabilization of neurotoxic Alzheimer amyloid- oligomers by protein engineering

5. A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils;Biochemistry;2022-01-26

2. Blood and Cerebrospinal Fluid Autoantibody to Aβ Levels in Patients with Alzheimer’s Disease: a Meta-Analysis Study;Journal of Molecular Neuroscience;2020-03-24

3. Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate;Bioorganic & Medicinal Chemistry;2019-03

4. Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system;Organic & Biomolecular Chemistry;2019

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