Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands-Reference-Cited by-同舟云学术

Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Published:2015 Issue:7 Volume:44 Page:3265-3270
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Rodríguez-Bárzano A.¹²³⁴⁵,Lord R. M.¹²³⁴⁵,Basri A. M.¹²³⁴⁵,Phillips R. M.⁶⁷⁸⁵,Blacker A. J.¹²³⁴⁵,McGowan P. C.¹²³⁴⁵

Affiliation:

1. School of Chemistry

2. University of Leeds

3. Woodhouse Lane

4. Leeds

5. UK

6. The Institute of Cancer Therapeutics

7. University of Bradford

8. Bradford

Abstract

A series of ruthenium complexes with η⁵-C₅(CH₃)₄R and diphosphine ligands have been synthesised and evaluated in vitro as anticancer agents. IC₅₀ values in the nanomolar range have been obtained against two types of cell lines.

Funder

Technology Strategy Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02748E

Reference26 articles.

1. Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes

2. Structure−Activity Relationships for Cytotoxic Ruthenium(II) Arene Complexes Containing N,N-, N,O-, and O,O-Chelating Ligands

3. The Design of Organometallic Ruthenium Arene Anticancer Agents

4. Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mono- and Bis-cyclopentadienyl Complexes of Ruthenium and Osmium;Comprehensive Organometallic Chemistry IV;2022

2. Silver(I) N-Heterocyclic Carbene Complexes Derived from Clotrimazole: Antiproliferative Activity and Interaction with an Artificial Membrane-Based Biosensor;Organometallics;2020-03-20

3. Novel tetranuclear ruthenium(II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo;European Journal of Medicinal Chemistry;2019-10

4. Organoruthenium(ii) nucleoside conjugates as colon cytotoxic agents;New Journal of Chemistry;2019

5. Synthesis, X-ray structure of organometallic ruthenium (II) p -cymene complexes based on P- and N- donor ligands and their in vitro antibacterial and anticancer studies;Journal of Organometallic Chemistry;2017-10