Organoruthenium(ii) nucleoside conjugates as colon cytotoxic agents
Author:
Affiliation:
1. Centro de Química Estrutural
2. Instituto Superior Técnico
3. Universidade de Lisboa
4. 1049-001 Lisboa
5. Portugal
6. Research Institute for Medicines (iMed.ULisboa)
7. Faculty of Pharmacy
8. 1649-003 Lisboa
Abstract
Eleven organoruthenium(ii) nucleoside conjugates are reported, showing high cytotoxicity in HCT116 colon cancer cells and independent uptake of nucleoside transporters.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C8NJ04515A
Reference42 articles.
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3. A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
4. From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
5. Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study
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