Amphiphilic mannose-6-phosphate glycopolypeptide-based bioactive and responsive self-assembled nanostructures for controlled and targeted lysosomal cargo delivery

Author:

Mondal Basudeb1234ORCID,Pandey Bhawana56748ORCID,Parekh Nimisha56748ORCID,Panda Sidharth1234ORCID,Dutta Tahiti1234ORCID,Padhy Abinash1234ORCID,Sen Gupta Sayam1234ORCID

Affiliation:

1. Department of Chemical Sciences

2. Indian Institute of Science Education and Research

3. Kolkata-741246

4. India

5. Polymer Science and Engineering Division

6. CSIR-National Chemical Laboratory

7. Pune - 411008

8. Academy of Scientific and Innovative Research

Abstract

M6P-receptors are overexpressed in specific cancer cells (such as breast cancer) and are also involved in the trafficking of mannose-6-phosphate labeled proteins exclusively onto lysosomes via cell surface M6P receptor (CI-MPR) mediated endocytosis.

Funder

Council of Scientific and Industrial Research, India

Indian Institute of Science Education and Research Kolkata

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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