Iron(ii)-catalyzed C-2 cyanomethylation of indoles and pyrroles via direct oxidative cross-dehydrogenative coupling with acetonitrile derivatives

Author:

Qiao Kai1234,Zhang Dong1234,Zhang Kai1234,Yuan Xin1234,Zheng Ming-Wei1234,Guo Tian-Fo1234ORCID,Fang Zheng1234,Wan Li12345,Guo Kai12345ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering

2. Nanjing Tech University

3. Nanjing 211816

4. P. R. China

5. Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM)

Abstract

A novel and efficient approach for the C(sp2)–H/C(sp3)–H oxidative coupling of indoles and pyrroles with acetonitrile derivatives was reported by using the Fe(ii) complex.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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1. The Recent Advances in Iron‐Catalyzed C(sp3)−H Functionalization;Chemistry – An Asian Journal;2024-01-26

2. Efficient iron-catalyzed direct acylation of amines with carboxylic acids and esters under oxygenated conditions;Catalysis Science & Technology;2024

3. Transition Metal‐Catalyzed C2 and C3 Functionalization of Indoles;Transition‐Metal‐Catalyzed C‐H Functionalization of Heterocycles;2023-03-25

4. Visible-Light-Promoted Direct C3-H Cyanomethylation of 2H-Indazoles;ACS Omega;2023-03-13

5. CH Activation of Indoles;Handbook of CH‐Functionalization;2022-10-02

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