1. Dipartimento di Chimica e Technologie del Farmaco,
Sapienza, Università di Roma, P.le A. Moro 5, 00185 Roma, Italy
2. This is a Chemical Reviews Perennial Review. The root paper of this title was
published in Chem. Rev.2005, 105 (7), 2873−2920, DOI: 10.1021/cr040639b; Published
(Web) July 13, 2005. Updates to the text appear in red type.