Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Author:

Jang Kyung-Jin1,Mehr Ali Poyan12,Hamilton Geraldine A.1,McPartlin Lori A.1,Chung Seyoon13,Suh Kahp-Yang4,Ingber Donald E.156

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering at Harvard University, CLSB Bldg. 5th floor, 3 Blackfan Circle, Boston, MA 02115 USA. Fax: +1 617-432-7048; Tel: +1 617-432-7044

2. Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA

3. Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA

4. School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742 South Korea

5. Vascular Biology Program, Departments of Pathology and Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA

6. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Reference66 articles.

1. Next-generation biomarkers for detecting kidney toxicity;Bonventre;Nat. Biotechnol.,2010

2. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?;Laverty;Br. J. Pharmacol.,2011

3. Drug-induced nephrotoxicity;Naughton;Am. Fam. Physician,2008

4. Impact and frequency of different toxicities throughout the pharmaceutical life cycle;Redfern;Toxicologist,2010

5. Renal vulnerability to drug toxicity;Perazella;Clin. J. Am. Soc. Nephrol.,2009

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